Shiri Z, Lévesque M, Etter G, Manseau F, Williams S, Avoli M. Optogenetic
Low-frequency stimulation of specific neuronal populations abates ictogenesis. J Neurosci. 2017 Feb 16. pii: 2244-16. doi: 10.1523/JNEUROSCI.2244-16.2017. PubMed.

Mahar I, Albuquerque MS, Mondragon-Rodriguez S, Cavanagh C, Davoli MA, Chabot JG, Williams S, Mechawar N, Quirion R, Krantic S. Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer’s Disease. Front Aging Neurosci. 2017 Jan 19;8:327. doi:10.3389/fnagi.2016.00327. PubMed.

Mondragón-Rodríguez S, Perry G, Pena-Ortega F, Williams S. Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer’s Disease. Curr Alzheimer Res. 2017;14(1):40-46. PubMed.

Huh CY, Amilhon B, Ferguson KA, Manseau F, Torres-Platas SG, Peach JP, Scodras
S, Mechawar N, Skinner FK, Williams S. Excitatory Inputs Determine Phase-Locking
Strength and Spike-Timing of CA1 Stratum Oriens/Alveus Parvalbumin and Somatostatin Interneurons during Intrinsically Generated Hippocampal Theta Rhythm. J Neurosci. 2016 Jun 22;36(25):6605-22. doi: 10.1523/JNEUROSCI.3951-13.2016. PubMed.

Boyce R, Glasgow SD, Williams S, Adamantidis A. Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation. Science. 2016 May 13;352(6287):812-6. doi: 10.1126/science.aad5252. PubMed.

Robinson J, Manseau F, Ducharme G, Amilhon B, Vigneault E, El Mestikawy S, Williams S. Optogenetic Activation of Septal Glutamatergic Neurons Drive Hippocampal Theta Rhythms. J Neurosci. 2016 Mar 9;36(10):3016-23. doi: 10.1523/JNEUROSCI.2141-15.2016. PubMed.

Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B. Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. Nat Neurosci. 2016 Apr;19(4):560-3. doi: 10.1038/nn.4245. PubMed.

Shiri Z, Manseau F, Lévesque M, Williams S, Avoli M. Activation of specific neuronal networks leads to different seizure onset types. Ann Neurol. 2016 Mar;79(3):354-65. doi: 10.1002/ana.24570. PubMed.

9: Ferguson KA, Huh CY, Amilhon B, Manseau F, Williams S, Skinner FK. Network
models provide insights into how oriens-lacunosum-moleculare and bistratified
cell interactions influence the power of local hippocampal CA1 theta oscillations. Front Syst Neurosci. 2015 Aug 7;9:110. doi: 10.3389/fnsys.2015.00110. PubMed.

Amilhon B, Huh CY, Manseau F, Ducharme G, Nichol H, Adamantidis A, Williams S. Parvalbumin Interneurons of Hippocampus Tune Population Activity at Theta Frequency. Neuron. 2015 Jun 3;86(5):1277-89. doi: 10.1016/j.neuron.2015.05.027. PubMed.

Shiri Z, Manseau F, Lévesque M, Williams S, Avoli M. Interneuron activity leads to initiation of low-voltage fast-onset seizures. Ann Neurol. 2015 Mar;77(3):541-6. doi: 10.1002/ana.24342. PubMed.

Ferguson KA, Huh CY, Amilhon B, Williams S, Skinner FK. Simple, biologically-constrained CA1 pyramidal cell models using an intact, whole hippocampus context. F1000Res. 2014 May 9;3:104. doi: 10.12688/f1000research.3894.1. PubMed.

Jackson J, Amilhon B, Goutagny R, Bott JB, Manseau F, Kortleven C, Bressler SL, Williams S. Reversal of theta rhythm flow through intact hippocampal circuits. Nat Neurosci. 2014 Aug 31.PubMed

Ferguson KA, Huh CY, Amilhon B, Williams S, Skinner FK. Experimentally constrained CA1 fast-firing parvalbumin-positive interneuron network models exhibit sharp transitions into coherent high frequency rhythms. Front Comput Neurosci. 2013 Oct 22;7:144.PubMed

Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Acevedo-Aquino MC, Williams S. Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer’s disease. Oxid Med Cell Longev. 2013;2013:940603.PubMed

Goutagny R, Loureiro M, Jackson J, Chaumont J, Williams S, Isope P, Kelche C, Cassel JC, Lecourtier L. Interactions between the Lateral Habenula and the Hippocampus: Implication for Spatial Memory Processes. Neuropsychopharmacology. 2013 Jun 5. Abstract / Full text

Gu N, Jackson J, Goutagny R, Lowe G, Manseau F, Williams S. NMDA-dependent phase synchronization between septal and temporal CA3 hippocampal networks. J Neuroscience 2013 May 8;33(19):8276-87. Abstract / Full text

Goutagny R, Gu N, Cavanagh C, Jackson J, Chabot JG, Quirion R, Krantic S, Williams S. Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer’s disease. European J. Neuroscience 2013 Jun;37(12):1896-902.Abstract / Full text

Ducharme*, G, Goutagny*, R , Lowe*, G, Williams S. Early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophrenia. PLoS One. 2012;7(1):e29754. Epub 2012 Jan 6. PubMed PMID: 22238649; PubMed Central PMCID: PMC3253085. Abstract / Full text

Jackson J, Goutagny R, Williams S. Fast and slow gamma rhythms are intrinsically and independently generated in the subiculum. J Neurosci. 2011 Aug 24;31(34):12104-17. PubMed PMID: 21865453. Abstract / Full text

Huh CY, Goutagny R, Williams S. Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm. J Neurosci. 2010 Nov 24;30(47):15951-61. PubMed PMID: 21106833. Abstract / Full text

Goutagny R, Jackson J, Williams S. Self-generated theta oscillations in the hippocampus. Nat Neurosci. 2009 Dec;12(12):1491-3. Epub 2009 Nov 1. PubMed PMID: 19881503. Abstract / Full text

Reviewed in the Nature Neuroscience NEWS AND VIEWS:
Hippocampal theta rhythms follow the beat of their own drum. By Colgin LL, Moser EI. Nat Neurosci. 2009 Dec;12(12):1483-4. Link

Huh CY, Danik M, Manseau F, Trudeau LE, Williams S. Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. J Neurosci. 2008 Feb 6;28(6):1404-9. PubMed PMID: 18256260.Abstract / Full text

Manseau F, Goutagny R, Danik M, Williams S. The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands: an investigation using a complete septohippocampal preparation in vitro. J Neurosci. 2008 Apr 9;28(15):4096-107. PubMed PMID: 18400909. Abstract / Full text

Katie A Ferguson, Carey YL Huh*, Bénédicte Amilhon*, Rosanah Murugesu, Sylvain Williams, Frances K Skinner. Experimentally constrained network model of hippocampal fast-firing parvalbumin-positive interneurons. BMC Neuroscience 2012, 13(Suppl 1):O5.

Siddhartha Mondragón-Rodríguez*, George Perry, Xiongwei Zhu, Paula I Moreira, and Sylvain Williams.
Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer’s Disease and a Therapeutic Target?
International Journal of Alzheimer’s Disease, vol. 2012, Article ID 276803, 4 pages. Abstract / Full text

Lowe*, G, Goutagny*, R, Ducharme*, G, Williams S. Early network alterations in the subiculum of offspring following gestational maternal infection. Schizophrenia Research Res. 2011 Dec 23 Abstract / Full text

Jackson*, J, Goutagny*, R, and Williams, S. Fast and slow gamma rhythms are intrinsically and independently generated in the subiculum. J.Neuroscience, 2011. Aug 24;31(34):12104-17. Abstract / Full text

Williams S, Boksa P. Gamma oscillations and schizophrenia. J Psychiatry Neurosci. 2010 Mar;35(2):75-7.
Abstract / Full text

Huh* CY L, Goutagny* R, and Williams S. Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm. J.Neuroscience 2010, November 24, 2010, 30(47):15951-15961. Abstract / Full text

Sanjeev K Bhardwaj, Moogeh Baharnoori , Bahram Sharif-Askari, Aarthi Kamath, Sylvain Williams, and Lalit K Srivastava. Behavioral characterization of dysbindin-1 deficient sandy mice. Behav Brain Res. 2008 Oct 15. Abstract / Full text

Lowe*, G, Danik*, M, Luheshi, GN, and Williams S. Prenatal infection and fever are associated with altered glutamatergic synaptic transmission in the hippocampus of juvenile offspring. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1563-71.
Abstract / Full text

Goutagny*, R, Manseau*, F, Jackson*, J, Danik*M, Williams S. In Vitro Activation of the Medial Septum—Diagonal Band Complex generates Atropine-Sensitive and Atropine-Resistant hippocampal Theta Rhythm: An Investigation Using a Complete Septohippocampal Preparation. Hippocampus. 2008;18(6):531-5.
Abstract / Full text

Huh* CYL, Danik* M, Manseau*, F, Trudeau L-E, Williams S. Chronic Exposure to Nerve Growth Factor Increases Acetylcholine and Glutamate Release from Cholinergic Neurons of the Rat Medial Septum and Diagonal Band of Broca via Mechanisms Mediated by p75NTR. J. Neuroscience. 2008;28 1404-1409.
Abstract / Full text

Manseau* F, Goutagny*, R, Danik*, M, & Williams, S. The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands; An investigation using a complete septohippocampal preparation in vitro. J. Neuroscience. 2008 Apr 9;28(15):4096-107.
Abstract / Full text

Mendez JA, Bourque, M-J, Mathieu L Bourdeau, Danik* M, Williams S, Lacaille, JC & Trudeau LE. Contact-dependent regulation of the neurotransmitter phenotype of dopamine neurons. J. Neuroscience 2008 Jun 18;28(25):6309-18.
Abstract / Full text

Aguilar-Valles* A, Poole S, Mistry Y, Williams S, & Luheshi GN. Attenuated fever in rats during late pregnancy is linked to suppressed IL-6 production after localised inflammation with turpentine. J. Physiol. 2007 Aug 15;583(Pt 1):391-403.
Abstract / Full text

Walker, C-D, Long, H, Williams, S. & Richard, D. Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits. J. Neurosci. Res. 2007 Mar;85(4):816-28.
Abstract / Full text


Book Chapters:

Goutagny R*. Jackson* J, Williams S. An intact septo-hippocampal preparation for investigating the mechanisms of hippocampal oscillation. Neuromethods . 2011. Humana press. Electrophysiological Recording Techniques.

Search for more publications by Sylvain Williams and collaborators on PubMed