Plot showing the loss of normal interaction between theta and gamma rhythm in an Alzheimer mice model. The loss of interaction or cross-frequency coupling, was an early abnormality appearing before memory deficits.

Plot showing the loss of normal interaction between theta and gamma rhythm in an Alzheimer mice model. The loss of interaction or cross-frequency coupling, was an early abnormality appearing before memory deficits.

These traces show that gamma frequency oscillations can be recorded without theta in the mice AD model.

These traces show that gamma frequency oscillations can be recorded without theta in the mice AD model.

We have recently shown that the interaction of theta and gamma rhythms in hippocampus may predict Alzheimer’s disease in AD mice models. We want to better understand the cellular mechanism underlying these early changes and find which molecules (ie beta-amyloid, etc) that trigger these early changes.

Article on this theme:

Goutagny et al., 2013. European Journal of Neuroscience